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Consequences of Untreated Iron Overload

Iron overload, also called iron toxicity, may lead to debilitating and life-threatening problems such as diabetes, heart failure, and poor growth (1-3).

Risks of Serum Ferritin > 1000 mcg/L

In both primary and secondary iron overload, serum ferritin >1000 mcg/L is associated with worsened prognosis (1,4).

When to treat iron toxicity

Transfusion Burden

As few as 10 lifetime red blood cell transfusions can result in transfusional iron toxicity (5, 6).

More about transfusional iron toxicity

Units* x 10 = Transfusional Iron Overload

*2 units may not always be included in
1 transfusion (eg, for pediatric patients).

References

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